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Tpoxx (Tecovirimat)


Protect yourself from the threat of monkeypox with Tpoxx, a safe and effective treatment option that has been proven to help combat the virus. Don’t let monkeypox put your health at risk – take action today by learning more about this essential therapy. Search for “monkeypox treatment,” “Tecovirimat,” or “viral infection prevention” to find out how Tpoxx can keep you safe and protected.

What is TPOXX?

TPOXX is a prescription medicine used to treat smallpox disease caused by a type of virus called variola virus in adults and children who weigh at least 7 pounds (3 kg).

  • The effectiveness of TPOXX has been studied only in animals with orthopoxvirus diseases. There have been no human studies in people who have smallpox disease.
  • The safety of TPOXX was studied in adults. There have been no studies in children 17 years of age and younger.
  • TPOXX may not work well in people who have a weakened immune system (immunocompromised).

TPOXX works as an antiviral by inhibiting the orthopoxvirus VP37 envelope wrapping protein.

What is TPOXX used for?

TPOXX is used to treat smallpox, a contagious, disfiguring and often deadly disease caused by the variola virus.

Naturally occurring smallpox was eradicated worldwide by 1980 through a global immunization campaign.

Samples of smallpox virus have been kept in laboratories for research purposes, leading to concerns of potential use as a biological warfare agent.

Who should not receive TPOXX injection?

Do not receive TPOXX injection if you or your child have severe kidney problems.

TPOXX injection contains an ingredient called hydroxypropyl β-cyclodextrin which is cleared from your body through the kidneys. Tell your healthcare provider if you or your child have kidney problems because receiving TPOXX injection may not be right for you or your child.

Before taking or receiving TPOXX

Before taking or receiving TPOXX, tell your healthcare provider about all of your or your child’s medical conditions, including if you or your child:

  • have diabetes.
  • have kidney problems.
  • are pregnant or plan to become pregnant. It is not known if this medicine can harm the unborn baby. Tell your healthcare provider if you or your child become pregnant during treatment.
  • are breastfeeding or plan to breastfeed. It is not known if this medicine passes into your breast milk. You should not breastfeed during treatment.
    • You should not breastfeed if you have smallpox because of the risk of passing variola virus to the breastfed infant.
    • Talk to your healthcare provider about the best way to feed your baby during treatment.
What other drugs will affect TPOXX?

Tell your healthcare provider about all of the medicines you or your child take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Using TPOXX with certain other medicines may affect each other causing possible serious side effects.

You can ask your healthcare provider or pharmacist for a list of medications that interact with TPOXX.

Especially tell your healthcare provider if you take a medicine used to treat type 2 diabetes called repaglinide.

Know the medicines you or your child take. Keep a list of your medicines to show your healthcare provider and pharmacist when you get a new medicine.

Do not start taking a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take TPOXX with other medicines.